Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice.

Cockroach allergen-induced eosinophilic airway inflammation in HLA-DQ/human CD4(+) transgenic mice.

Airway eosinophilic inflammation is a characteristic feature of allergic asthma. Exposure to allergens produced by the German cockroach (Blattella germanica) is a risk factor for allergic disease in genetically predisposed individuals, and has been linked to an increase in asthma morbidity among cockroach-sensitive inner city children. To determine the role and contribution of specific HLA clas...

Nasal Sensitization with Ragweed Pollen Induces Local-Allergic-Rhinitis-Like Symptoms in Mice

Recently, the concept of local allergic rhinitis (LAR) was established, namely rhinitis symptoms with local IgE production and negative serum antigen-specific IgE. However, the natural course of LAR development and the disease pathogenesis is poorly understood. This study investigated the pathophysiology of mice with allergic rhinitis that initially sensitized with ragweed pollen through the na...

Ragweed Group 5 Antigens a Distinct Set of Epitopes on Short and Giant Recognize Respond to Ragweed Allergens and HLA-DQ6 and HLA-DQ8 Transgenic Mice

B cell-intrinsic MyD88 signaling is essential for IgE responses in lungs exposed to pollen allergens.

Allergen-specific IgE is linked to asthma pathogenesis, but the underlying mechanisms of IgE production in response to allergen exposure are poorly understood. In this article, we show that B cell-intrinsic MyD88 is essential for IgE/IgG1 production evoked by ragweed pollen instilled into lungs. MyD88-deficient mice showed defective IgE/IgG1 production and germinal center responses to lung inst...

ALUNG April 22/4

Van Scott, Michael R., J. Paul Justice, John F. Bradfield, Edward Enright, Anastasia Sigounas, and Sanjiv Sur. IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice. Am J Physiol Lung Cell Mol Physiol 278: L667–L674, 2000.—We investigated the effects of interleukin (IL)-10 administration on allergen-induced Th2 cytokine production, eosinophilic i...